Sall4 regulates neuromesodermal progenitors and their descendants during body elongation in mouse embryos

The Lyman Break Galaxies: their progenitors and descendants

We study the evolution of Lyman Break Galaxies (LBGs) from z = 5 to z = 0 by tracing the merger trees of galaxies in a large-scale hydrodynamic simulation based on a Λ cold dark matter model. In particular, we emphasize on the range of properties of the sample selected by the rest-frame V band luminosity, in accordance with recent near-IR observations. The predicted rest-frame V band luminosity...

Neuromesodermal progenitors and the making of the spinal cord

Neuromesodermal progenitors (NMps) contribute to both the elongating spinal cord and the adjacent paraxial mesoderm. It has been assumed that these cells arise as a result of patterning of the anterior neural plate. However, as the molecular mechanisms that specify NMps in vivo are uncovered, and as protocols for generating these bipotent cells from mouse and human pluripotent stem cells in vit...

Assessing the bipotency of in vitro-derived neuromesodermal progenitors

Retrospective clonal analysis in the mouse has demonstrated that the posterior spinal cord neurectoderm and paraxial mesoderm share a common bipotent progenitor. These neuromesodermal progenitors (NMPs) are the source of new axial structures during embryonic rostrocaudal axis elongation and are marked by the simultaneous co-expression of the transcription factors T(Brachyury) (T(Bra)) and Sox2....

Early molecular events during retinoic acid induced differentiation of neuromesodermal progenitors

Bipotent neuromesodermal progenitors (NMPs) residing in the caudal epiblast drive coordinated body axis extension by generating both posterior neuroectoderm and presomitic mesoderm. Retinoic acid (RA) is required for body axis extension, however the early molecular response to RA signaling is poorly defined, as is its relationship to NMP biology. As endogenous RA is first seen near the time whe...

Generation, selection and transcriptomic profiling of human neuromesodermal and spinal cord progenitors in vitro